Abstract
Nine new gentisyl alcohol derivatives, namely, the trimeric terrestrol A (8), dimeric terrestrols B-H (1-7), and a monomeric derivative (12), together with four known analogues (9-11, 13) were isolated from the marine-derived fungus Penicillium terrestre. The structures of the new compounds were elucidated by spectroscopic methods including one- and two-dimensional NMR as well as low- and high-resolution mass spectrometric analysis. These new compounds (1-8, 12) showed cytotoxic effects on HL-60, MOLT-4, BEL-7402, and A-549 cell lines with IC50 values in the range 5-65 microM. Compound 6 also showed moderate inhibitory activity against protein tyrosine kinases (Src and KDR). Furthermore, all new compounds exhibited moderate radical scavenging activity against DPPH with IC50 values in the range 2.6-8.5 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Benzyl Alcohols / chemistry
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Benzyl Alcohols / isolation & purification*
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Benzyl Alcohols / pharmacology
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Biphenyl Compounds
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China
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Drug Screening Assays, Antitumor
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology
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Humans
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Inhibitory Concentration 50
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Marine Biology
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Molecular Structure
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Penicillium / chemistry*
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Picrates / pharmacology
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Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors
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src-Family Kinases / antagonists & inhibitors
Substances
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Antineoplastic Agents
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Benzyl Alcohols
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Biphenyl Compounds
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Free Radical Scavengers
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Picrates
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1,1-diphenyl-2-picrylhydrazyl
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Vascular Endothelial Growth Factor Receptor-2
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src-Family Kinases
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2,5-dihydroxybenzyl alcohol