Estrogen play the important role in normal current of inflammatory process. At age oppression of synthesis or at surgical menopause in an organism it is formed estrogen-deficiency syndrome shown in particular, in salivary glands change, loss of a jaw bones, disseminated current of inflammatory processes. For study of hormone replacing estrogen's therapy role in experiment, we determine the influence of transdermal estrogen-consisting systems on structure and function of large salivary glands, density of a bone jaws and current of infectious-inflammatory process in laboratory animals. For hormone-replacing estrogen-therapy we used an equivalent doze of estrogen-consisting plaster with a doze of estradiol 0.32 mg per day. The plaster pasted once a week on the ear. Criteria of efficiency were: calculation of bone destruction areas, pathology study of glandulars parotid and densitometries. The received experimental data testify to efficiency of application hormone-replacing estrogen's therapy in inflammatory diseases of maxillofacial area proceeding on a background of estrogen-deficiency.