Mixed ductal-endocrine carcinoma derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreas identified by human telomerase reverse transcriptase (hTERT) expression

J Surg Oncol. 2008 Apr 1;97(5):469-75. doi: 10.1002/jso.20959.

Abstract

We report a case of mixed ductal-endocrine carcinoma derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The tumor presented intermingled exocrine and endocrine carcinomatous components and expressed intense human telomerase reverse transcriptase (hTERT), further confirming the malignant features. This pathologically unique tumor is the first case of mixed ductal-endocrine carcinoma derived from pancreatic IPMN and telomerase activation could play a potential role in the neoplastic progression of mixed ductal-endocrine carcinomas of the pancreas.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma, Mucinous / metabolism*
  • Adenocarcinoma, Mucinous / pathology
  • Aged
  • Biomarkers, Tumor / metabolism
  • Carcinoma, Islet Cell / metabolism*
  • Carcinoma, Islet Cell / pathology
  • Carcinoma, Pancreatic Ductal / metabolism*
  • Carcinoma, Pancreatic Ductal / pathology
  • Carcinoma, Papillary / metabolism*
  • Carcinoma, Papillary / pathology
  • Humans
  • Immunohistochemistry
  • Male
  • Neoplasms, Second Primary / metabolism*
  • Neoplasms, Second Primary / pathology
  • Pancreatic Neoplasms / metabolism*
  • Pancreatic Neoplasms / pathology
  • Telomerase / metabolism*

Substances

  • Biomarkers, Tumor
  • TERT protein, human
  • Telomerase