Abstract
The anticryptosporidial activity of Bobel-24 (2,4,6-triiodophenol) was studied for the first time, resulting in a reduction of the in vitro growth of Cryptosporidium of up to 99.6%. In a SCID mouse model of chronic cryptosporidiosis, significant differences (P < 0.05) in oocyst shedding were observed in animals treated with 125 mg/kg/day. These results merit further investigation of Bobel-24 as a chemotherapeutic option for cryptosporidiosis.
MeSH terms
-
Animals
-
Antiprotozoal Agents* / chemistry
-
Antiprotozoal Agents* / pharmacology
-
Antiprotozoal Agents* / therapeutic use
-
Cryptosporidiosis / drug therapy*
-
Cryptosporidiosis / parasitology
-
Cryptosporidium parvum / drug effects*
-
Cryptosporidium parvum / growth & development
-
Culture Media
-
Disease Models, Animal*
-
Female
-
Humans
-
Mice
-
Mice, SCID
-
Phenols* / chemistry
-
Phenols* / pharmacology
-
Phenols* / therapeutic use
-
Treatment Outcome
Substances
-
Antiprotozoal Agents
-
Culture Media
-
Phenols
-
2,4,6-triiodophenol