Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of cefditoren-pivoxil

David Sevillano; Lorenzo Aguilar; Luis Alou; María-José Giménez; Martha Torrico; Natalia González; Fabio Cafini; María-Teresa Relaño; Pilar Coronel; José Prieto

doi:10.1128/AAC.01247-07

Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of cefditoren-pivoxil

Antimicrob Agents Chemother. 2008 Mar;52(3):1184-6. doi: 10.1128/AAC.01247-07. Epub 2007 Dec 26.

Authors

David Sevillano¹, Lorenzo Aguilar, Luis Alou, María-José Giménez, Martha Torrico, Natalia González, Fabio Cafini, María-Teresa Relaño, Pilar Coronel, José Prieto

Affiliation

¹ Microbiology Department, School of Medicine, Universidad Complutense, Avda. Complutense s/n, 28040 Madrid, Spain.

Abstract

Activity of simulated cefditoren urinary concentrations was determined against seven Escherichia coli isolates. Bactericidal activity was obtained from 4 to 24 h against TEM-1 (penicillinase production/hyperproduction), TEM-34 (IRT-6), and TEM-116 (extended-spectrum beta-lactamase [ESBL]) and from 6 to 8 h against SHV/TEM-116 (ESBL) but never against SHV/TEM-1 (ESBL). Extension of bactericidal activity depended on the resistance genotype/phenotype tested.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amdinocillin Pivoxil* / administration & dosage
Amdinocillin Pivoxil* / pharmacokinetics
Amdinocillin Pivoxil* / pharmacology
Anti-Bacterial Agents* / administration & dosage
Anti-Bacterial Agents* / pharmacokinetics
Anti-Bacterial Agents* / pharmacology
Anti-Infective Agents, Urinary* / administration & dosage
Anti-Infective Agents, Urinary* / pharmacokinetics
Anti-Infective Agents, Urinary* / pharmacology
Cephalosporins* / administration & dosage
Cephalosporins* / pharmacokinetics
Cephalosporins* / pharmacology
Escherichia coli / drug effects*
Escherichia coli / enzymology
Escherichia coli / genetics
Escherichia coli / isolation & purification
Escherichia coli Infections / microbiology
Genotype
Humans
Microbial Sensitivity Tests
Models, Biological
Phenotype
Urinary Tract Infections / microbiology
Urine / chemistry*
Urine / microbiology
beta-Lactamases / biosynthesis

Substances

Anti-Bacterial Agents
Anti-Infective Agents, Urinary
Cephalosporins
Amdinocillin Pivoxil
cefditoren
beta-Lactamases