Comparative evaluation of two combined measles-mumps-rubella vaccines based on AIK and Edmonston- Zagreb strains of measles virus

Kitasato Arch Exp Med. 1991 Sep;64(2-3):141-7.

Abstract

In a previous paper, we have noticed the effectiveness of two further attenuated measles vaccines, i.e. AIK-HDC and Edmonston- Zagreb- HDC. In the present study the same strains are comparatively used for immunization of a limited number of children under 9 months of age. A seroconversion of 100% was observed. Following reimmunization, a significant increase of circulating antibodies for both strains was recorded. Two combined measles-mumps-rubella (MMR) vaccines were also produced by using the same measles strains. The seroconversion following utilisation of MMR prophylactics in susceptible children was 98.8 and 97.3 for AIK and Edmonston- Zagreb strains respectively.

Publication types

  • Comparative Study

MeSH terms

  • Antibodies, Viral / biosynthesis
  • Child, Preschool
  • Drug Combinations
  • Evaluation Studies as Topic
  • Female
  • Humans
  • Immunization
  • Infant
  • Male
  • Measles Vaccine / immunology*
  • Measles virus / classification*
  • Measles virus / immunology
  • Measles-Mumps-Rubella Vaccine
  • Mumps Vaccine / immunology*
  • Mumps virus / immunology
  • Rubella Vaccine / immunology*
  • Rubella virus / immunology
  • Vaccines, Attenuated / immunology

Substances

  • Antibodies, Viral
  • Drug Combinations
  • Measles Vaccine
  • Measles-Mumps-Rubella Vaccine
  • Mumps Vaccine
  • Rubella Vaccine
  • Vaccines, Attenuated