Construction and validation of an automated flow hydrogenation instrument for application in high-throughput organic chemistry

J Comb Chem. 2008 Jan-Feb;10(1):88-93. doi: 10.1021/cc700178a. Epub 2007 Dec 21.

Abstract

This manuscript details the construction of a fully automated flow hydrogenation apparatus for use in high-throughput organic synthesis. The instrument comprises of a Bohdan robot platform coupled with a ThalesNano H-cube hydrogenator and a series of solvent valves and pumping mechanisms. Using this instrument, we have been able to fully automate a number of key transformations that could not otherwise be conveniently undertaken in a high-throughput manner.

MeSH terms

  • Catalysis
  • Chemistry, Organic / instrumentation*
  • Chemistry, Organic / methods
  • Combinatorial Chemistry Techniques / instrumentation*
  • Combinatorial Chemistry Techniques / methods
  • Drug Design*
  • Equipment Design
  • Hydrogenation
  • Reproducibility of Results
  • Robotics*
  • Small Molecule Libraries / chemistry

Substances

  • Small Molecule Libraries