Diffuse-type giant cell tumor (D-TGCT) is relatively rare. We report a case of multicentric D-TGCT located in the finger and wrist. A 79-year-old man presented with a more than two-year history of tumors. Marginal resection was performed. Histological study of the specimens disclosed D-TGCT. Recurrence occurred two years and five months postoperatively and was again excised. Clinical presentation, radiological features and histopathological findings are discussed with reference to the literature.