Long-term persistence of memory B cells specific for hepatitis B surface antigen in HIV-1-infected patients

Edouard Tuaillon; Yassine Al Tabaa; Vincent Baillat; Gaël Petitjean; Jacques Reynes; Jean Pierre Vendrell

doi:10.1097/QAD.0b013e32827035b5

Long-term persistence of memory B cells specific for hepatitis B surface antigen in HIV-1-infected patients

AIDS. 2007 Nov 12;21(17):2343-5. doi: 10.1097/QAD.0b013e32827035b5.

Authors

Edouard Tuaillon¹, Yassine Al Tabaa, Vincent Baillat, Gaël Petitjean, Jacques Reynes, Jean Pierre Vendrell

Affiliation

¹ Laboratoire de Virologie, Hôpital Lapeyronie, Montpellier, France.

PMID: 18090284
DOI: 10.1097/QAD.0b013e32827035b5

Abstract

To investigate the maintenance of long-term memory B cells specific for hepatitis B surface antigen (HBsAg), purified blood B cells were polyclonally stimulated and cells secreting antibodies directed to HBsAg (HBs-SC) enumerated by ELISpot. HBs-SC were found in 18/20 HIV-1-infected patients with either natural or vaccinal immunity to hepatitis B virus, including six subjects with serum anti-hepatitis B surface antibody levels less than 10 mIU/ml. A lower number of HBs-SC was found in HBsAg-vaccinated patients compared with vaccinated controls.

MeSH terms

Anti-HIV Agents / therapeutic use
Antibodies, Viral / analysis
B-Lymphocytes / immunology*
B-Lymphocytes / virology
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
HIV Infections / drug therapy
HIV Infections / immunology*
HIV Infections / virology
HIV-1*
Hepatitis B Surface Antigens / blood*
Hepatitis B Surface Antigens / immunology
Hepatitis B Vaccines / administration & dosage
Hepatitis B virus / immunology*
Hepatitis B, Chronic / immunology*
Hepatitis B, Chronic / prevention & control
Hepatitis B, Chronic / virology
Humans
Immunologic Memory
Lymphocyte Activation
Lymphocyte Count
Statistics, Nonparametric
Time Factors

Substances

Anti-HIV Agents
Antibodies, Viral
Hepatitis B Surface Antigens
Hepatitis B Vaccines