Abstract
Chronic kidney disease (CKD) causes various bone mineral disorders, which have recently been named CKD mineral and bone disorder (CKD-MBD). CKD-MBD is associated with extremely high cardiovascular disease (CVD) morbidity and mortality in the endstage kidney disease (ESKD) population. Thus, optimal management of CKD-MBD would lead to a reduction in cardiovascular morbidity and mortality in uremic patients. In addition, it has been suggested that the treatment of CKD-MBD has some favorable effects on the progression of CKD. Recently, novel therapeutic agents, including active vitamin D analogues, noncalcium-containing phosphate binders, and cinacalcet, have become clinically available. In this article, we review novel therapeutic strategies for CKD-MBD.
MeSH terms
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Aniline Compounds / therapeutic use
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Bone Diseases, Metabolic / complications
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Bone Diseases, Metabolic / drug therapy*
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Bone Diseases, Metabolic / etiology
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Bone Diseases, Metabolic / metabolism
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Calcium Metabolism Disorders / drug therapy
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Calcium Metabolism Disorders / etiology
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Cardiovascular Diseases / drug therapy
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Cardiovascular Diseases / etiology*
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Cardiovascular Diseases / metabolism
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Chelating Agents / therapeutic use*
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Cinacalcet
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Disease Progression
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Humans
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Hyperparathyroidism, Secondary / drug therapy
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Hyperparathyroidism, Secondary / etiology
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Hyperphosphatemia / drug therapy
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Hyperphosphatemia / etiology
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Lanthanum / therapeutic use
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Naphthalenes / therapeutic use
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Phenethylamines
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Polyamines / therapeutic use
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Propylamines
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Renal Insufficiency, Chronic / complications*
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Renal Insufficiency, Chronic / drug therapy
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Renal Insufficiency, Chronic / metabolism
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Sevelamer
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Vitamin D / analogs & derivatives
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Vitamin D / therapeutic use
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Vitamin D Deficiency / drug therapy
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Vitamin D Deficiency / etiology
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Vitamins / therapeutic use*
Substances
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Aniline Compounds
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Chelating Agents
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N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine
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Naphthalenes
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Phenethylamines
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Polyamines
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Propylamines
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Vitamins
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Vitamin D
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lanthanum carbonate
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Lanthanum
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Sevelamer
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Cinacalcet