Abstract
Sulfiredoxin and sestrin are cysteine sulfinic acid reductases that selectively reduce or repair the hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. As such these enzymes play key roles in the modulation of peroxide-mediated cell signaling and cellular defense mechanisms. The unique structure of sulfiredoxin facilitates access to the peroxiredoxin active site and novel sulfur chemistry.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Cysteine / analogs & derivatives
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Cysteine / chemistry
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Cysteine / metabolism
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Eukaryotic Cells / enzymology*
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Heat-Shock Proteins / chemistry
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Heat-Shock Proteins / metabolism*
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Oxidation-Reduction
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Oxidoreductases Acting on Sulfur Group Donors / chemistry
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Oxidoreductases Acting on Sulfur Group Donors / metabolism*
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Peroxides / chemistry
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Peroxides / metabolism
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Peroxiredoxins / chemistry
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Peroxiredoxins / metabolism*
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Signal Transduction / physiology
Substances
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Heat-Shock Proteins
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Peroxides
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Peroxiredoxins
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Oxidoreductases Acting on Sulfur Group Donors
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Cysteine
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cysteine sulfinic acid