Abstract
A new bicyclic peptide of RA-series, RA-XVIII (3), was isolated from the roots of Rubia cordifolia L. Its structure was established to be a hydroxylated derivative of RA-VII by the semi-synthesis of 3 from deoxybouvardin, and its cytotoxicity against P-388 cells was 0.012 microg/mL.
MeSH terms
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Bridged Bicyclo Compounds / chemical synthesis
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Bridged Bicyclo Compounds / chemistry*
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Bridged Bicyclo Compounds / pharmacology*
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Cell Line, Tumor
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Humans
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Oligopeptides / chemical synthesis
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Oligopeptides / chemistry*
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Oligopeptides / pharmacology*
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Protein Conformation
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Rubia / chemistry*
Substances
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Bridged Bicyclo Compounds
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Oligopeptides