We report a new case of a patient suffering from chronic hepatitis C (CHC) and treated with interferon-alpha2a (IFN-alpha) who presented with the diagnosis of active pulmonary tuberculosis. Interferon was stopped and appropriate treatment with antituberculous drugs initiated. Several weeks later the patient was free of clinical symptoms. Our case demonstrates a rare association between interferon and tuberculosis since only one case in the literature has described a similar association.