An outbreak of carbapenem-resistant Acinetobacter baumannii producing OXA-23 carbapenemase in western China

Int J Antimicrob Agents. 2008 Jan;31(1):50-4. doi: 10.1016/j.ijantimicag.2007.08.019.

Abstract

Twenty-two non-repetitive carbapenem-resistant Acinetobacter baumannii isolates were obtained from Intensive Care Unit patients. All of the isolates carried bla(OXA-23), bla(OXA-66), a novel cephalosporinase-encoding gene (bla(ADC-25)) and a class 1 integron with an aacC1-orfP-orfQ-aadA1a cassette array and had identical enterobacterial repetitive intergenic consensus (ERIC) profiles. ISAba1 was found upstream of bla(OXA-23), but was not associated with bla(OXA-66) or bla(ADC-25).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / epidemiology*
  • Acinetobacter Infections / microbiology*
  • Acinetobacter baumannii / drug effects*
  • Acinetobacter baumannii / isolation & purification
  • Carbapenems / pharmacology*
  • China / epidemiology
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Disease Outbreaks*
  • Drug Resistance, Bacterial / genetics*
  • Humans
  • Integrons
  • Intensive Care Units
  • Interspersed Repetitive Sequences
  • Molecular Sequence Data
  • Sequence Analysis, DNA
  • beta-Lactamases / biosynthesis
  • beta-Lactamases / genetics*

Substances

  • Carbapenems
  • DNA, Bacterial
  • beta-Lactamases

Associated data

  • GENBANK/EF016355
  • GENBANK/EF016356
  • GENBANK/EF016357
  • GENBANK/EF033072
  • GENBANK/EF033073