Background & objective: Cisplatin (DDP) in large dosage impairs renal functions, while the impact of fractionated low dose DDP on renal functions is unclear. This study was to evaluate the effects of fractionated low dose DDP on renal functions of gastric cancer patients.
Methods: From Sep. 1998 to Jun. 2002, 31 gastric cancer patients were treated with LFEP regimen at School of Oncology of Peking University: intravenous administration of calcium folinate (CF, 150 mg/m(2)) at Day 1-3, 5-fluorouracil (5-FU, 500 mg/m(2)) at Day 1-5, epirubicin (EPI, 60 mg/m(2)) at Day 1, and DDP (20 mg/m(2)) at Day 1-3. Urine N-acetyl-beta-D-glucosaminidase (NAG), gamma-glutamyl transferase (gamma-GT) and routine urine test were assessed before chemotherapy and every other day during the 14-day chemotherapy; serum creatinine (sCr) and urea nitrogen (BUN) were assessed at the 7th day and 14th day during treatment.
Results: Of the 31 patients, 13 had normal renal functions before chemotherapy, while only 1 had normal renal functions after chemotherapy. Urine NAG and gamma-GT were changed significantly after chemotherapy: they were increased significantly on the 4th day and maintained higher than normal level for another 14 days thereafter. Meanwhile, no significant change in sCr and BUN were observed.
Conclusion: Combined chemotherapy with fractionated low dose DDP still adversely affects renal functions of gastric cancer patients, however, the long-term effects need to be clarified.