Abstract
The data available in the literature data on the role of neoangiogenesis and extracellular matrix factors in the pathogenesis of acute and chronic leukemias and lymphoproliferative diseases are presented. Hematopoiesis and endothelial cells have a common pluripotential progenitor. Angiogenic and fibroblast growth factors are involved chronic leukemia. The phenotype of lymphoid cells determines the type of the cellular and extracellular factors.
MeSH terms
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Acute Disease
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Angiogenesis Inducing Agents / metabolism*
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Animals
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Chronic Disease
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Endothelial Cells / metabolism
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Endothelial Cells / pathology
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Extracellular Matrix / metabolism
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Extracellular Matrix / pathology
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Fibroblast Growth Factors / metabolism*
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Fibroblasts / metabolism
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Fibroblasts / pathology
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Hematopoiesis
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Humans
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Leukemia / metabolism*
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Leukemia / pathology
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Lymphocytes / metabolism
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Lymphocytes / pathology
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Lymphoproliferative Disorders / metabolism*
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Lymphoproliferative Disorders / pathology
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Neovascularization, Pathologic / metabolism*
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Neovascularization, Pathologic / pathology
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Stem Cells / metabolism*
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Stem Cells / pathology
Substances
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Angiogenesis Inducing Agents
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Fibroblast Growth Factors