Abstract
The first stereoselective synthesis of meso-secoisolariciresinol is reported. A comparison of the cytotoxic and immunosuppressive activity between meso-secoisolariciresinol and optically active secoisolariciresinols was similarly performed for the first time. Both enantiomers of secoisolariciresinol accelerated IgM production, although meso-secoisolariciresinol did not affect IgM production. Only meso-secoisolariciresinol showed cytotoxic activity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Butylene Glycols / chemical synthesis*
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Butylene Glycols / chemistry
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Butylene Glycols / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Humans
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Immunoglobulin M / biosynthesis
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Immunosuppressive Agents / chemical synthesis*
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Immunosuppressive Agents / chemistry
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Immunosuppressive Agents / pharmacology
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Lignans / chemical synthesis*
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Lignans / chemistry
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Lignans / pharmacology
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Mice
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Mice, Inbred BALB C
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Stereoisomerism
Substances
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Antineoplastic Agents
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Butylene Glycols
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Immunoglobulin M
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Immunosuppressive Agents
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Lignans
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secoisolariciresinol