A flexible method for the fabrication of gold nanostructures using oligonucleotide derivatives

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1605-9. doi: 10.1080/15257770701548675.

Abstract

Several linear and branched DNA structures from 80-200 nm with a biotine molecule in the middle have been prepared. These structures have been decorated by addition of positively charged gold nanoparticles carrying 4-(dimethylamino)pyridine ligands. Streptavidin binds to the central biotine molecule introducing a 20 nm gap in the structure in which a biotinylated nanoparticle can be introduced. The simplest structure (80 nm, linear) is formed by 4 oligonucleotides. By changing some of these components changes on length, shape, and recognition system easily can be introduced.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biotin / chemistry
  • DNA / chemistry
  • Gold / chemistry*
  • Ligands
  • Metal Nanoparticles / chemistry*
  • Microscopy, Atomic Force
  • Nanotechnology / methods*
  • Oligodeoxyribonucleotides / chemistry*
  • Pyridines / chemistry
  • Streptavidin / chemistry

Substances

  • 4-(dimethylamine)pyridine
  • Ligands
  • Oligodeoxyribonucleotides
  • Pyridines
  • Biotin
  • Gold
  • DNA
  • Streptavidin