New cationic polyprenyl derivative proposed as a lipofecting agent

Acta Biochim Pol. 2007;54(4):873-6. Epub 2007 Dec 8.

Abstract

Cationic linear poly-cis-isoprenoid prepared from natural plant polyprenol in a mixture with dioleyl phosphatidylethanolamine was found to be an effective lipofection agent for eukaryotic cells. The transfecting activity is related to the poly-cis structure of the polyprenyl chain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cations
  • Cell Line, Tumor
  • Humans
  • Lipids / chemistry*
  • Male
  • Molecular Structure
  • Neoprene / chemistry*
  • Phosphatidylethanolamines / chemistry
  • Plants / chemistry
  • Transfection*

Substances

  • Cations
  • Lipids
  • Phosphatidylethanolamines
  • prenyl
  • phosphatidylethanolamine
  • Neoprene