In human genome, generation of a nuclear export signal through duplication appears unique to nucleophosmin (NPM1) mutations and is restricted to AML

Leukemia. 2008 Jun;22(6):1285-9. doi: 10.1038/sj.leu.2405045. Epub 2007 Dec 6.

Authors

A Liso, A Bogliolo, V Freschi, M P Martelli, S A Pileri, M Santodirocco, N Bolli, M F Martelli, B Falini

PMID: 18059485
DOI: 10.1038/sj.leu.2405045

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Computational Biology
Cytoplasm / metabolism
Gene Duplication*
Genome, Human*
Humans
Immunoenzyme Techniques
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / pathology
Mutation / genetics*
Nuclear Export Signals*
Nuclear Proteins / genetics*
Nucleophosmin
Peptide Fragments / physiology

Substances

NPM1 protein, human
Nuclear Export Signals
Nuclear Proteins
Peptide Fragments
Nucleophosmin