Furano- and pyrrolo [2,3-d] pyrimidine nucleosides and their 5'-O-triphospates: synthesis and enzymatic activity

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1083-6. doi: 10.1080/15257770701516250.

Abstract

A series of bicyclic [2,3-d]furano- and pyrrolopyrimidine ribonucleosides were synthesized and converted chemically into corresponding 5'-O-triphosphates. Substrate properties of the triphosphates toward some RNA and DNA polymerases are reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / chemistry
  • Antiviral Agents / metabolism
  • Antiviral Agents / pharmacology
  • Bridged Bicyclo Compounds / chemical synthesis
  • Bridged Bicyclo Compounds / chemistry
  • Bridged Bicyclo Compounds / metabolism
  • Cattle
  • DNA-Directed DNA Polymerase / metabolism
  • DNA-Directed RNA Polymerases / metabolism
  • Drug Design
  • HIV Reverse Transcriptase / antagonists & inhibitors
  • Hepacivirus / drug effects
  • Hepacivirus / enzymology
  • Molecular Structure
  • Pyrimidine Nucleosides / chemical synthesis*
  • Pyrimidine Nucleosides / chemistry
  • Pyrimidine Nucleosides / metabolism*
  • Pyrimidine Nucleosides / pharmacology
  • Pyrimidine Nucleotides / chemical synthesis*
  • Pyrimidine Nucleotides / chemistry
  • Pyrimidine Nucleotides / metabolism*
  • Pyrimidine Nucleotides / pharmacology
  • Substrate Specificity

Substances

  • Antiviral Agents
  • Bridged Bicyclo Compounds
  • Pyrimidine Nucleosides
  • Pyrimidine Nucleotides
  • HIV Reverse Transcriptase
  • DNA-Directed RNA Polymerases
  • DNA-Directed DNA Polymerase