Stereoselective synthesis of 1'-functionalized-4'-thionucleosides

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1011-4. doi: 10.1080/15257770701508588.

Abstract

Stereoselective functionalization of the 1'-position of 4'-thionucleosides was achieved using a stereoselective S(N)2 reaction controlled by 5-membered ring coordination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine A3 Receptor Antagonists
  • Drug Design
  • Humans
  • Hydrogen Bonding
  • Stereoisomerism
  • Thionucleosides / chemical synthesis*
  • Thionucleosides / chemistry
  • Thionucleosides / pharmacology

Substances

  • Adenosine A3 Receptor Antagonists
  • Thionucleosides