5'-carbamoylphosphonyl-[6-3H]-AZT as a tool for studying metabolic transformations of the nonradioactive counterpart, an inhibitor of HIV replication

Dmitry V Yanvarev; Elena A Shirokova; Maria V Astapova; Vyacheslav I Shram; Marina K Kukhanova; Yury S Skoblov

doi:10.1080/15257770701505899

5'-carbamoylphosphonyl-[6-3H]-AZT as a tool for studying metabolic transformations of the nonradioactive counterpart, an inhibitor of HIV replication

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):897-900. doi: 10.1080/15257770701505899.

Authors

Dmitry V Yanvarev¹, Elena A Shirokova, Maria V Astapova, Vyacheslav I Shram, Marina K Kukhanova, Yury S Skoblov

Affiliation

¹ Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. JDmitry@hotmail.com

PMID: 18058504
DOI: 10.1080/15257770701505899

Abstract

An effective synthesis of 5'-carbamoylphosphonyl-[6-3H]-AZT was developed from [6-3H]-AZT. For the synthesized compound, chemical and enzymatic stability were determined and its penetration across HL-60 cell membranes was studied.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-HIV Agents / chemistry
Anti-HIV Agents / pharmacokinetics
Anti-HIV Agents / pharmacology
Biotransformation
Dogs
Drug Design
Drug Stability
HL-60 Cells
Half-Life
Humans
In Vitro Techniques
Rabbits
Tritium
Zidovudine / analogs & derivatives*
Zidovudine / chemistry
Zidovudine / pharmacokinetics
Zidovudine / pharmacology

Substances

Anti-HIV Agents
Tritium
Zidovudine