Molecular characterization of three new virulent Newcastle disease virus variants isolated in China

J Clin Microbiol. 2008 Feb;46(2):750-3. doi: 10.1128/JCM.01587-07. Epub 2007 Dec 5.

Abstract

Three cases of Newcastle disease virus (NDV) found in nature had the lentogenic motif (112)G-R-Q-G-R-L(117) in their fusion protein cleavage sites. However, both intracerebral pathogenicity and intravenous pathogenicity indexes showed that these NDV isolates were virulent. In comparison with the LaSota live virus vaccine, these viruses had significant genetic variations in the hemagglutinin-neuraminidase gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Birds
  • China / epidemiology
  • Cluster Analysis
  • HN Protein / genetics*
  • Molecular Sequence Data
  • Newcastle Disease / epidemiology
  • Newcastle Disease / virology*
  • Newcastle disease virus / genetics
  • Newcastle disease virus / isolation & purification*
  • Newcastle disease virus / pathogenicity*
  • Phylogeny
  • Sequence Analysis, DNA
  • Sequence Homology
  • Viral Fusion Proteins / genetics*
  • Virulence

Substances

  • HN Protein
  • Viral Fusion Proteins

Associated data

  • GENBANK/DQ228930
  • GENBANK/DQ228934
  • GENBANK/DQ234580