Abstract
Antibacterial agents are used in malaria therapy due to their effect on two prokaryote organelles, the mitochondrion and the apicoplast. We demonstrate here that the ribosome-blocking antibiotics telithromycin and quinupristin-dalfopristin, but not linezolid, inhibit the growth of Plasmodium falciparum. Both drugs induce delayed death in the parasite, suggesting that their effect involves the impairment of apicoplast translation processes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Humans
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Ketolides / pharmacology*
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Malaria, Falciparum / parasitology
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Parasitic Sensitivity Tests
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / growth & development*
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Protein Biosynthesis / drug effects
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Protein Synthesis Inhibitors / pharmacology*
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Time Factors
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Virginiamycin / pharmacology*
Substances
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Ketolides
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Protein Synthesis Inhibitors
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Virginiamycin
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quinupristin-dalfopristin
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telithromycin