Abstract
Four new ST-1435 derivatives 4-7 were synthesized. Both 4 and 5 are mixture of Z- and E-isomers. 4 was separated into Z- and E-isomers by spinning TLC. Their binding ability to progesterone receptor was examined and found to be less than ST-1435.
MeSH terms
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Animals
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Breast Feeding
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Contraceptive Agents, Female / chemical synthesis*
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Female
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Lactation
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Norprogesterones / chemical synthesis*
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Norprogesterones / metabolism
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Rats
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Receptors, Progesterone / metabolism
Substances
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Contraceptive Agents, Female
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Norprogesterones
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Receptors, Progesterone
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ST 1435