Abstract
FoxO3 regulates the transcription of critical components of the ubiquitin-proteasome system in muscle wasting. Two reports (Mammucari et al., 2007; Zhao et al., 2007) now implicate FoxO3 in the transcription of autophagy-related genes and provide the first direct evidence for a coordinated role of autophagy in muscle atrophy.
MeSH terms
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Animals
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Autophagy / genetics
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Autophagy / physiology
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Forkhead Box Protein O3
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Forkhead Transcription Factors / metabolism*
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Humans
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Models, Biological
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Muscle, Skeletal / metabolism*
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Muscular Atrophy / etiology
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Peptide Hydrolases / metabolism*
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Proteasome Endopeptidase Complex / metabolism
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Transcription, Genetic
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Ubiquitin / metabolism
Substances
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FOXO3 protein, human
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Forkhead Box Protein O3
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Forkhead Transcription Factors
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FoxO3 protein, mouse
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Ubiquitin
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Peptide Hydrolases
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Proteasome Endopeptidase Complex