FoxO3 controls dangerous proteolytic liaisons

Cell Metab. 2007 Dec;6(6):425-7. doi: 10.1016/j.cmet.2007.11.005.

Abstract

FoxO3 regulates the transcription of critical components of the ubiquitin-proteasome system in muscle wasting. Two reports (Mammucari et al., 2007; Zhao et al., 2007) now implicate FoxO3 in the transcription of autophagy-related genes and provide the first direct evidence for a coordinated role of autophagy in muscle atrophy.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autophagy / genetics
  • Autophagy / physiology
  • Forkhead Box Protein O3
  • Forkhead Transcription Factors / metabolism*
  • Humans
  • Models, Biological
  • Muscle, Skeletal / metabolism*
  • Muscular Atrophy / etiology
  • Peptide Hydrolases / metabolism*
  • Proteasome Endopeptidase Complex / metabolism
  • Transcription, Genetic
  • Ubiquitin / metabolism

Substances

  • FOXO3 protein, human
  • Forkhead Box Protein O3
  • Forkhead Transcription Factors
  • FoxO3 protein, mouse
  • Ubiquitin
  • Peptide Hydrolases
  • Proteasome Endopeptidase Complex