[Positively charged acyl derivatives of carbohydrates as promising transfection agents]

Bioorg Khim. 2007 Sep-Oct;33(5):538-43. doi: 10.1134/s1068162007050068.
[Article in Russian]

Abstract

A convenient approach to the synthesis of mono- and polycationic glycolipid amphiphiles is suggested. The compounds obtained can be used for study of the structure-activity relationship and determination of the effect of hydrophobic and cationic domains on transfection efficiency.

MeSH terms

  • Acylation
  • Animals
  • Carbohydrates / chemical synthesis
  • Carbohydrates / chemistry
  • Glycolipids / chemical synthesis
  • Glycolipids / chemistry*
  • Liposomes / chemistry
  • Polyamines / chemical synthesis
  • Polyamines / chemistry*
  • Polyelectrolytes
  • Transfection*

Substances

  • Carbohydrates
  • Glycolipids
  • Liposomes
  • Polyamines
  • Polyelectrolytes
  • polycations