Retinal angiomatous proliferation reactivation 6 months after high-dose intravitreal acetonide triamcinolone and photodynamic therapy

Eur J Ophthalmol. 2007 Nov-Dec;17(6):979-82. doi: 10.1177/112067210701700619.

Abstract

Purpose: To describe the incidence of retinal angiomatous proliferation (RAP) reactivation after combined treatment with a high-dose intravitreal triamcinolone acetonide (IVTA) and photodynamic therapy (PDT) at 1-year follow-up.

Methods: All patients had undergone a full ophthalmic examination. High-dose IVTA (20 mg) was injected via pars plana. Four to 7 days later, PDT was delivered.

Results: Fourteen eyes of 13 patients were included. Eight lesions (57%) reopened and needed retreatment with combined therapy at 6 months follow-up. At 1-year follow up, the lesion was obliterated in nine cases (64.2%) and best-corrected visual acuity improved from 0.87 logMar (range, 0.7-1) to 0.79 logMar (range, 0.5-1).

Conclusions: Combined therapy using high-dose IVTA and PDT is beneficial in stabilizing RAP. However, a high incidence of RAP reactivation has been observed at 6 months, even with a high-dose IVTA injection.

MeSH terms

  • Angiomatosis / diagnosis
  • Angiomatosis / drug therapy
  • Angiomatosis / etiology*
  • Combined Modality Therapy
  • Female
  • Fluorescein Angiography
  • Glucocorticoids / administration & dosage*
  • Glucocorticoids / therapeutic use
  • Humans
  • Incidence
  • Male
  • Photochemotherapy*
  • Prospective Studies
  • Recurrence
  • Retinal Neovascularization / diagnosis
  • Retinal Neovascularization / drug therapy
  • Retinal Neovascularization / etiology*
  • Retreatment
  • Tomography, Optical Coherence
  • Triamcinolone Acetonide / administration & dosage*
  • Triamcinolone Acetonide / therapeutic use
  • Visual Acuity

Substances

  • Glucocorticoids
  • Triamcinolone Acetonide