The high levels of air pollutants over the North-Western Mediterranean (NWM) exceed the thresholds set in current air quality regulations. They demand a detailed diagnosis of those areas where the exceedances of thresholds related to human health are found. In this sense, there is a need for modelling studies for the specific area of the NWM that take into account the annual cycle to address the diagnosis of air pollution. A new approach to the modelling of air quality in the NWM has been adopted by combining the WRF-EMICAT-CMAQ-DREAM modelling system to diagnose the current status of the levels of photochemical air pollution (focusing on ozone, O(3); nitrogen dioxide, NO(2); carbon monoxide, CO; and particulate matter, PM10) in the area during an annual cycle (year 2004). The complexity of the area of study requires the application of high spatial and temporal resolution (2 km and 1 h). The annual simulations need to cover the complex different meteorological situations and types of episodes of air pollution in the area of study. The outputs of the modelling system are evaluated against observations from 52 meteorological and 59 air quality stations belonging to the Environmental Department of the Catalonia Government (Spain), which involve a dense and accurate spatial distribution of stations in the territory (32,215 km(2)). The results indicate a good behaviour of the model in both coastal and inland areas of the NWM, with a slight trend to the overestimation of tropospheric O(3) concentrations and the underestimation of other photochemical pollutants (NO(2), CO and PM10). The modelling diagnosis indicates that the main air quality-related problems in the NWM are the exceedances of the 1-hr O(3) information threshold set in the Directive 2002/3/EC (180 microg m(-3)) as a consequence of the transport of O(3) precursors downwind the Barcelona Greater Area (BGA); and the exceedances of the annual value for the protection of human health for NO(2) and PM10 (40 microg m(-3), Directive 1999/30/EC), both in the BGA, as a consequence of the high traffic-related emissions.