Coenzyme Q10 does not protect cochlear hair cells from death in the ischemic organotypic culture

Otolaryngol Head Neck Surg. 2007 Dec;137(6):950-2. doi: 10.1016/j.otohns.2007.09.001.

Abstract

Objective: To evaluate in vitro the effect of coenzyme Q10 (CoQ(10)) on ischemia-induced hair cell death.

Study design: Organotypic cochlear cultures of newborn rats were subjected to ischemia with and without CoQ(10).

Results: Addition of CoQ(10) has not prevented HC loss.

Conclusion: CoQ(10) seems to protect against only certain modes of cell death.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Carbon Dioxide / pharmacology
  • Cell Death / drug effects
  • Cell Survival / drug effects
  • Coenzymes / pharmacology
  • Electron Transport Chain Complex Proteins / pharmacology*
  • Hair Cells, Auditory / drug effects*
  • Ischemia / physiopathology*
  • Nitrogen / pharmacology
  • Organ Culture Techniques
  • Perilymph / physiology
  • Protective Agents / pharmacology*
  • Rats
  • Rats, Wistar
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / pharmacology

Substances

  • Coenzymes
  • Electron Transport Chain Complex Proteins
  • Protective Agents
  • Ubiquinone
  • Carbon Dioxide
  • coenzyme Q10
  • Nitrogen