Synthesis and PC3 androgen-independent prostate cells antiproliferative effect of fagaronine derivatives

J Enzyme Inhib Med Chem. 2007 Oct;22(5):647-54. doi: 10.1080/14756360701485901.

Abstract

Fagaronine derivatives syntheses were optimized and their effect on PC3 androgen-independent prostate cell line was evaluated. An assessment of the lipophilicity of the benzo[c]phenanthridine derivatives was achieved at pH 7.4 and et 6.7 by determining log D.

MeSH terms

  • Adenocarcinoma / drug therapy*
  • Alkaloids / chemistry*
  • Alkaloids / therapeutic use
  • Androgens / metabolism*
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Benzophenanthridines
  • Cell Line, Tumor
  • Cell Proliferation / drug effects*
  • Drug Resistance, Neoplasm / drug effects
  • Drug Screening Assays, Antitumor
  • Humans
  • Hydrogen-Ion Concentration / drug effects
  • Male
  • Molecular Structure
  • Phenanthridines / chemical synthesis
  • Phenanthridines / chemistry*
  • Phenanthridines / pharmacology
  • Phenanthridines / therapeutic use
  • Prostatic Neoplasms / drug therapy*

Substances

  • Alkaloids
  • Androgens
  • Antineoplastic Agents
  • Benzophenanthridines
  • Phenanthridines
  • fagaronine