New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

Paulino Delgado-Méndez; Nora Herrera; Haydee Chávez; Ana Estévez-Braun; Angel G Ravelo; Fernando Cortes; Santiago Castanys; Francisco Gamarro

doi:10.1016/j.bmc.2007.10.071

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

Bioorg Med Chem. 2008 Feb 1;16(3):1425-30. doi: 10.1016/j.bmc.2007.10.071. Epub 2007 Nov 26.

Authors

Paulino Delgado-Méndez¹, Nora Herrera, Haydee Chávez, Ana Estévez-Braun, Angel G Ravelo, Fernando Cortes, Santiago Castanys, Francisco Gamarro

Affiliation

¹ Instituto Universitario de Bio-Orgánica 'Antonio González', Universidad de La Laguna. Avda. Astrofísico Fco. Sánchez No 2, 38206, La Laguna, Tenerife, Spain.

PMID: 18035546
DOI: 10.1016/j.bmc.2007.10.071

Abstract

Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel beta-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiprotozoal Agents / chemistry*
Antiprotozoal Agents / pharmacology*
Drug Resistance, Multiple / drug effects*
Leishmania / drug effects*
Magnetic Resonance Spectroscopy
Maytenus / chemistry*
Molecular Structure
Structure-Activity Relationship
Terpenes / chemistry*
Terpenes / pharmacology*

Substances

Antiprotozoal Agents
Terpenes