Atypical acute graft-versus-host disease

Am J Dermatopathol. 2007 Dec;29(6):576-7. doi: 10.1097/DAD.0b013e3181594f6d.

Abstract

Acute graft-versus-host disease (GVHD) is a life-threatening complication of allogeneic bone marrow transplantation. It is important to recognize the dermatologic manifestations of acute GVHD, as skin is often the initial organ of involvement. We present a case of acute GVHD characterized by rare clinical and histopathologic findings as only two erythematous nodules clinically and abrupt follicular wall necrosis histopathologically.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Bone Marrow Transplantation / adverse effects*
  • Cyclosporine / therapeutic use
  • Erythema / etiology
  • Erythema / pathology
  • Graft vs Host Disease / drug therapy
  • Graft vs Host Disease / etiology
  • Graft vs Host Disease / pathology*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Methotrexate / therapeutic use
  • Necrosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / surgery
  • Skin Diseases / etiology
  • Skin Diseases / pathology*
  • Treatment Outcome

Substances

  • Immunosuppressive Agents
  • Cyclosporine
  • Methotrexate