The role of specific agricultural pesticides in relation to adult and childhood cancers has not been firmly established due to the lack of precise exposure data in previous studies. Improvements in exposure assessment, disease classification, and application of molecular techniques in recent epidemiological evaluations is rapidly improving our ability to evaluate the human carcinogenicity of agricultural pesticides. The role of pesticide exposures in the etiology of human cancer is outlined by anatomical site and recent development in exposure assessment and molecular epidemiology are summarized and evaluated.