Abstract
Sulfonylurea receptor 1 (SUR1) is a molecule with more diverse and critically important functions than previously recognized. Long viewed simply as a subunit involved in formation of a subset of K(ATP) channels, accumulating evidence indicates that SUR1 is newly upregulated in CNS ischemia and injury and is surprisingly promiscuous in its association with different pore-forming subunits, which endow it with new roles not previously envisioned. In this review, we focus on the SUR1-regulated NC(Ca-ATP) channel, its emerging role in CNS ischemia and trauma, and the growing evidence from preclinical and clinical studies demonstrating the potential importance of block of SUR1 by sulfonylureas such as glibenclamide (glyburide) in conditions as seemingly diverse as stroke and spinal cord injury.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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ATP-Binding Cassette Transporters / antagonists & inhibitors*
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ATP-Binding Cassette Transporters / physiology
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Animals
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Brain Ischemia / drug therapy*
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Humans
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KATP Channels / physiology
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Potassium Channel Blockers / therapeutic use*
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Potassium Channels / physiology
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Potassium Channels, Inwardly Rectifying / antagonists & inhibitors*
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Potassium Channels, Inwardly Rectifying / physiology
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Receptors, Drug / antagonists & inhibitors*
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Receptors, Drug / physiology
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Spinal Cord Injuries / drug therapy*
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Stroke / drug therapy*
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Sulfonylurea Receptors
Substances
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ABCC8 protein, human
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ATP-Binding Cassette Transporters
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KATP Channels
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Potassium Channel Blockers
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Potassium Channels
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Potassium Channels, Inwardly Rectifying
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Receptors, Drug
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Sulfonylurea Receptors