Abstract
An approach was developed for the synthesis of 5'-branched neplanocin A, as potential inhibitors against S-adenosyl-L-homocysteine hydrolase. The vinyl-stannane system of the key synthetic intermediate (14) in the present study, was prepared by radical-mediated sulfur-extrusive stannylation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine / analogs & derivatives*
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Adenosine / chemical synthesis
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Adenosine / chemistry
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Adenosylhomocysteinase / antagonists & inhibitors
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Enzyme Inhibitors / chemistry
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Free Radicals / chemistry
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Organotin Compounds / chemical synthesis
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Organotin Compounds / chemistry*
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Sulfur / chemistry
Substances
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5'-(tributyltin)-2',3'-O-isopropylidene-4'-trityladenosine
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Antiviral Agents
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Enzyme Inhibitors
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Free Radicals
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Organotin Compounds
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Sulfur
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neplanocin A
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Adenosylhomocysteinase
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Adenosine