Synthesis of 5'-branched neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation

Nucleic Acids Symp Ser (Oxf). 2007:(51):145-6. doi: 10.1093/nass/nrm073.

Abstract

An approach was developed for the synthesis of 5'-branched neplanocin A, as potential inhibitors against S-adenosyl-L-homocysteine hydrolase. The vinyl-stannane system of the key synthetic intermediate (14) in the present study, was prepared by radical-mediated sulfur-extrusive stannylation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / chemical synthesis
  • Adenosine / chemistry
  • Adenosylhomocysteinase / antagonists & inhibitors
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Enzyme Inhibitors / chemistry
  • Free Radicals / chemistry
  • Organotin Compounds / chemical synthesis
  • Organotin Compounds / chemistry*
  • Sulfur / chemistry

Substances

  • 5'-(tributyltin)-2',3'-O-isopropylidene-4'-trityladenosine
  • Antiviral Agents
  • Enzyme Inhibitors
  • Free Radicals
  • Organotin Compounds
  • Sulfur
  • neplanocin A
  • Adenosylhomocysteinase
  • Adenosine