A new concept in double duplex DNA invasion by chiral PNAs which simultaneously depress PNA-PNA and improve PNA-DNA duplex stability

Stefano Sforza; Tullia Tedeschi; Roberto Corradini; Rosangela Marchelli

doi:10.1093/nass/nrm010

A new concept in double duplex DNA invasion by chiral PNAs which simultaneously depress PNA-PNA and improve PNA-DNA duplex stability

Nucleic Acids Symp Ser (Oxf). 2007:(51):19-20. doi: 10.1093/nass/nrm010.

Authors

Stefano Sforza¹, Tullia Tedeschi, Roberto Corradini, Rosangela Marchelli

Affiliation

¹ Department of Organic and Industrial Chemistry, Viale G.P. Usberti 17a, University Campus, University of Parma, I-43100 - Parma, Italy. stefano.sforza@unipr.it

PMID: 18029565
DOI: 10.1093/nass/nrm010

Abstract

By using suitably designed chiral, lysine-based PNAs (chPNAs), the stability of complementary chPNAchPNA duplexes can be depressed, maintaining or improving at the same time the stability of the corresponding PNA-DNA duplexes. This approach could be used in order to develop chPNAs able to perform double duplex DNA invasion.

MeSH terms

DNA / chemistry*
Lysine / chemistry
Nucleic Acid Denaturation
Peptide Nucleic Acids / chemical synthesis
Peptide Nucleic Acids / chemistry*
Stereoisomerism

Substances

Peptide Nucleic Acids
DNA
Lysine