Abstract
Co-translational protein targeting by the signal recognition particle (SRP) relies on a complex series of structural rearrangements in the SRP and its receptor (SR). In order to precisely coordinate the individual steps, the GTPases of the SRP and the SR form a unique complex in which GTP hydrolysis is activated in a composite active site. A recent study provides new insights on the link between the GTPases and protein translocation.
MeSH terms
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Bacterial Proteins / chemistry*
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Bacterial Proteins / metabolism*
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Bacterial Proteins / physiology
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Enzyme Activation / physiology
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GTP Phosphohydrolases / chemistry*
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GTP Phosphohydrolases / metabolism*
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GTP Phosphohydrolases / physiology
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Protein Transport / physiology
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Signal Recognition Particle / chemistry
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Signal Recognition Particle / physiology*
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Thermus / enzymology
Substances
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Bacterial Proteins
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Signal Recognition Particle
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GTP Phosphohydrolases