Matrix metalloproteinase-1, -3, and -9 gene polymorphisms and the risk of idiopathic dilated cardiomyopathy in a Chinese Han population

Clin Biochem. 2007 Dec;40(18):1427-30. doi: 10.1016/j.clinbiochem.2007.09.013. Epub 2007 Oct 3.

Abstract

Objectives: To investigate the association between matrix metalloproteinase (MMP)-1(-1607 1G/2G), MMP-3(-1171 5A/6A), and MMP-9(-1562 C/T) polymorphism and susceptibility to idiopathic dilated cardiomyopathy (IDCM).

Design and methods: MMP-1, -3, -9 genotypes were determined by PCR-RFLP analysis.

Results: Genotype frequency of MMP-3, but not MMP-1 and MMP-9 in IDCM patients, was significantly different from that in healthy controls.

Conclusions: Our data suggested that MMP-3 5A/6A polymorphism could be a risk factor for the susceptibility to IDCM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cardiomyopathy, Dilated / genetics*
  • Case-Control Studies
  • China
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Matrix Metalloproteinase 1 / genetics*
  • Matrix Metalloproteinase 3 / genetics*
  • Matrix Metalloproteinase 9 / genetics*
  • Middle Aged
  • Polymorphism, Genetic*
  • Population Groups / genetics
  • Risk Factors

Substances

  • MMP3 protein, human
  • Matrix Metalloproteinase 3
  • Matrix Metalloproteinase 9
  • MMP1 protein, human
  • Matrix Metalloproteinase 1