Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases)

Microbes Infect. 2007 Nov-Dec;9(14-15):1644-51. doi: 10.1016/j.micinf.2007.09.004. Epub 2007 Sep 14.

Abstract

IRG proteins (also known as p47 GTPases) are key mediators of interferon-gamma-induced resistance to pathogens. Absence of certain IRG proteins leads to profound susceptibility to protozoa and bacteria in mice. Underlying their roles in host resistance, IRG proteins regulate the processing of pathogen-containing vacuoles in host cells, and regulate hematopoiesis following infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Bacteria / pathogenicity
  • Bacterial Infections / immunology*
  • Bacterial Infections / microbiology
  • Eukaryota / pathogenicity
  • GTP Phosphohydrolases / genetics
  • GTP Phosphohydrolases / metabolism*
  • Host-Pathogen Interactions
  • Humans
  • Immunity, Innate*
  • Interferon-gamma / genetics
  • Interferon-gamma / metabolism*
  • Macrophages* / microbiology
  • Macrophages* / parasitology
  • Mice
  • Mice, Knockout
  • Protozoan Infections / immunology*
  • Protozoan Infections / parasitology

Substances

  • Interferon-gamma
  • GTP Phosphohydrolases