There are depicted immediate results of treatment of the patients, suffering multifocal atherosclerosis, using endovascular methods. Of 21 patients, suffering atherosclerotic affection of carotid and coronary arteries, in 16 endovascular interventions were performed and in 5--combined endovascular and surgical interventions. In all the patients the stenting procedure was accomplished using mechanical neuroprotective devices. In the patients, to whom aorto-coronary shunting was indicated, as a first stage of treatment the interventions on extracranial basin was performed and in 3-4 weeks afterwards--the aorto-coronary shunting operation. The order of the procedures performance in the patients was dependent on the leading clinical symptoms severity. The total of 23 carotid and 46 coronary stents was implanted in the group observed. There were no mortality afer endovascular interventions performance. Non-Q myocardium infarction had occurred in a patient, suffering affection of several coronary arteries, and the transient disorder of the brain blood flow--in a patient during the carotid stenting performance.