The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes

Org Biomol Chem. 2007 Aug 21;5(16):2555-9. doi: 10.1039/b708635k.

Abstract

A family of terpyridine metallo-organic complexes has been designed and its recognition properties of G-quadruplex-DNA investigated. The series combines easy synthetic access and good affinity-selectivity ratio for quadruplex-DNA. Our study also highlights that the geometry of the metal center strongly governs the ability of the compounds to discriminate quadruplex from duplex-DNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding, Competitive
  • Crystallography, X-Ray
  • Fluorescence Resonance Energy Transfer
  • G-Quadruplexes*
  • Ligands
  • Metals, Heavy / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Nucleic Acid Conformation
  • Organometallic Compounds / chemical synthesis
  • Organometallic Compounds / chemistry*
  • Pyridines / chemistry*
  • Structure-Activity Relationship

Substances

  • Ligands
  • Metals, Heavy
  • Organometallic Compounds
  • Pyridines