Selank and its metabolites maintain homeostasis in the gastric mucosa

Bull Exp Biol Med. 2007 Jan;143(1):51-3. doi: 10.1007/s10517-007-0014-1.

Abstract

Antiulcer properties of a synthetic anxiolytic Selank and in vivo formed metabolites of this compound were studied on 3 experimental models of ulceration. The test peptides decreased the area of experimental gastric ulcers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetic Acid
  • Animals
  • Anti-Ulcer Agents / metabolism
  • Anti-Ulcer Agents / pharmacology*
  • Anti-Ulcer Agents / therapeutic use
  • Ethanol
  • Gastric Mucosa / drug effects*
  • Gastric Mucosa / pathology
  • Homeostasis
  • Male
  • Oligopeptides / metabolism
  • Oligopeptides / pharmacology*
  • Oligopeptides / therapeutic use
  • Rats
  • Rats, Wistar
  • Stomach Ulcer / etiology
  • Stomach Ulcer / pathology
  • Stomach Ulcer / prevention & control*
  • Stress, Psychological / complications

Substances

  • Anti-Ulcer Agents
  • Oligopeptides
  • Ethanol
  • Acetic Acid
  • TP 7