Abstract
Synthesis of several pryrazolo[4,3-e][1,2,4]-triazines is described. The absorption spectrum of some 5-substituted derivatives was found to extend to the visible region. These compounds were found to inhibit some enzymes of purine metabolism, like xanthine oxidase or bacterial purine-nucleoside phosphorylase with Ki values in the 10(-3) -10(-5) M range.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Absorption
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Animals
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Cattle
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Cultured Milk Products / enzymology
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Drug Evaluation
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Escherichia coli / enzymology
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Guanine Deaminase / antagonists & inhibitors
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Guanine Deaminase / metabolism
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Light*
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Models, Biological
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Muscles / enzymology
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Purine-Nucleoside Phosphorylase / antagonists & inhibitors
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Purine-Nucleoside Phosphorylase / metabolism
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Purines / chemistry*
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Purines / metabolism
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Purines / pharmacology
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Pyrazoles / chemistry*
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Pyrazoles / pharmacology
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Rabbits
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Triazines / chemistry*
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Triazines / pharmacology
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Xanthine Oxidase / antagonists & inhibitors
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Xanthine Oxidase / metabolism
Substances
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Enzyme Inhibitors
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Purines
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Pyrazoles
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Triazines
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Xanthine Oxidase
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Purine-Nucleoside Phosphorylase
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Guanine Deaminase