Pyrazolo[4,3-e][1,2,4]triazines: purine analogues with electronic absorption in the visible region

Molecules. 2005 Oct 31;10(10):1298-306. doi: 10.3390/10101298.

Abstract

Synthesis of several pryrazolo[4,3-e][1,2,4]-triazines is described. The absorption spectrum of some 5-substituted derivatives was found to extend to the visible region. These compounds were found to inhibit some enzymes of purine metabolism, like xanthine oxidase or bacterial purine-nucleoside phosphorylase with Ki values in the 10(-3) -10(-5) M range.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorption
  • Animals
  • Cattle
  • Cultured Milk Products / enzymology
  • Drug Evaluation
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Escherichia coli / enzymology
  • Guanine Deaminase / antagonists & inhibitors
  • Guanine Deaminase / metabolism
  • Light*
  • Models, Biological
  • Muscles / enzymology
  • Purine-Nucleoside Phosphorylase / antagonists & inhibitors
  • Purine-Nucleoside Phosphorylase / metabolism
  • Purines / chemistry*
  • Purines / metabolism
  • Purines / pharmacology
  • Pyrazoles / chemistry*
  • Pyrazoles / pharmacology
  • Rabbits
  • Triazines / chemistry*
  • Triazines / pharmacology
  • Xanthine Oxidase / antagonists & inhibitors
  • Xanthine Oxidase / metabolism

Substances

  • Enzyme Inhibitors
  • Purines
  • Pyrazoles
  • Triazines
  • Xanthine Oxidase
  • Purine-Nucleoside Phosphorylase
  • Guanine Deaminase