Abstract
The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2 and CYP 2E1 were investigated. The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP1A2, while AOSC-971 induced the CYP 2E1 in male rats. The results are useful for their safety evaluation, as well as for the prediction of inter-drug interactions associated with the two drugs.
MeSH terms
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Animals
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Caffeine / pharmacokinetics
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Central Nervous System Stimulants / pharmacokinetics
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Chlorzoxazone / pharmacokinetics
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Cytochrome P-450 CYP1A2 / metabolism*
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Cytochrome P-450 CYP2E1 / metabolism*
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Dose-Response Relationship, Drug
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Drug Interactions*
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Female
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Male
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Mannans* / chemistry
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Mannans* / pharmacokinetics
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Mannans* / pharmacology
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Muscle Relaxants, Central / pharmacokinetics
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Polysaccharides* / chemistry
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Polysaccharides* / pharmacokinetics
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Polysaccharides* / pharmacology
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Random Allocation
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Rats
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Rats, Wistar
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Sex Factors
Substances
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Central Nervous System Stimulants
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Mannans
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Muscle Relaxants, Central
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Polysaccharides
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acidic oligosaccharide sugar chain, Echlonia Kurome Okam
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sulfated polymannuroguluronate
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Caffeine
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Cytochrome P-450 CYP2E1
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Cytochrome P-450 CYP1A2
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Chlorzoxazone