Comparative studies of the effects of two novel sugar drug candidates on the CYP 1A2 and CYP 2E1 enzymes in different sexed rats using a "cocktail" approach

Molecules. 2004 Nov 30;9(11):978-87. doi: 10.3390/91100978.

Abstract

The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2 and CYP 2E1 were investigated. The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP1A2, while AOSC-971 induced the CYP 2E1 in male rats. The results are useful for their safety evaluation, as well as for the prediction of inter-drug interactions associated with the two drugs.

Publication types

  • Evaluation Study

MeSH terms

  • Animals
  • Caffeine / pharmacokinetics
  • Central Nervous System Stimulants / pharmacokinetics
  • Chlorzoxazone / pharmacokinetics
  • Cytochrome P-450 CYP1A2 / metabolism*
  • Cytochrome P-450 CYP2E1 / metabolism*
  • Dose-Response Relationship, Drug
  • Drug Interactions*
  • Female
  • Male
  • Mannans* / chemistry
  • Mannans* / pharmacokinetics
  • Mannans* / pharmacology
  • Muscle Relaxants, Central / pharmacokinetics
  • Polysaccharides* / chemistry
  • Polysaccharides* / pharmacokinetics
  • Polysaccharides* / pharmacology
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Sex Factors

Substances

  • Central Nervous System Stimulants
  • Mannans
  • Muscle Relaxants, Central
  • Polysaccharides
  • acidic oligosaccharide sugar chain, Echlonia Kurome Okam
  • sulfated polymannuroguluronate
  • Caffeine
  • Cytochrome P-450 CYP2E1
  • Cytochrome P-450 CYP1A2
  • Chlorzoxazone