Isolation and X-ray crystal structure of tetrahydroisoquinoline alkaloids from Calycotome villosa Subsp. intermedias

Ali El Antri; Ibtissam Messouri; Mohamed Bouktaib; Rachid El Alami; Michael Bolte; Brahim El Bali; Mohammed Lachkar

doi:10.3390/90800650

Isolation and X-ray crystal structure of tetrahydroisoquinoline alkaloids from Calycotome villosa Subsp. intermedias

Molecules. 2004 Jul 31;9(8):650-7. doi: 10.3390/90800650.

Authors

Ali El Antri¹, Ibtissam Messouri, Mohamed Bouktaib, Rachid El Alami, Michael Bolte, Brahim El Bali, Mohammed Lachkar

Affiliation

¹ Laboratoire d'Analyses, d'Essais et d'Environnement (L.A.E.E.), Département de Chimie, Faculté des Sciences Dhar Mehraz, Université Sidi Mohamed Ben Abdellah, 30000 Fès, Morocco.

Abstract

Two tetrahydroisoquinoline alkaloids were extracted from the alkaloid fraction of a methanol extract of the seeds of Calycotome Villosa Subsp. intermedia. Their structures were established as (R)-1-hydroxymethyl-7-8-dimethoxy-1,2,3,4-tetrahydro- isoquinoline (1) and (S)-7-hydroxymethyl-2-3-dimethoxy-7,8,9,10-tetrahydroisoquinoline chloride (2) by spectroscopic techniques and X-ray diffraction analysis.

MeSH terms

Alkaloids / chemistry*
Alkaloids / isolation & purification*
Crystallography, X-Ray
Magnoliopsida / chemistry*
Models, Molecular
Tetrahydroisoquinolines / chemistry*
Tetrahydroisoquinolines / isolation & purification*

Substances

Alkaloids
Tetrahydroisoquinolines