Hyperbranched molecular structures with potential antiviral activity: derivatives of 5,6-dihydroxyindole-2-carboxylic Acid

Mario Sechi; Fabio Casu; Ilaria Campesi; Stefano Fiori; Alberto Mariani

doi:10.3390/11120968

Hyperbranched molecular structures with potential antiviral activity: derivatives of 5,6-dihydroxyindole-2-carboxylic Acid

Molecules. 2006 Dec 18;11(12):968-77. doi: 10.3390/11120968.

Authors

Mario Sechi¹, Fabio Casu, Ilaria Campesi, Stefano Fiori, Alberto Mariani

Affiliation

¹ Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy. mario.sechi@uniss.it

Abstract

In the search of new HIV-1 integrase (IN) inhibitors, we synthesized a series of multimeric 5,6-dihydroxyindole-2-carboxylic acid (DHICA) derivatives. Preliminary results indicate that hyperbranched architectures could represent a peculiar molecular requisite for the development of new antiviral lead compounds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemistry*
Antiviral Agents / pharmacology*
Cell Line
HIV-1 / drug effects
Humans
Indoles / chemistry*
Indoles / pharmacology*
Microbial Sensitivity Tests

Substances

Antiviral Agents
Indoles
5,6-dihydroxy-2-indolylcarboxylic acid