Abstract
The Pechmann reaction of substituted phenols 1a-e with methyl acetoacetate (2) can be activated by boron trifluoride dihydrate (3) to give the corresponding 4-methyl- coumarin derivatives 4a-e in excellent yield (98-99 %).
MeSH terms
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Benzene Derivatives / chemistry
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Boranes / chemistry*
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Coumarins / chemistry*
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Indicators and Reagents
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Kinetics
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Phenols / chemistry*
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Thermodynamics
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Water
Substances
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Benzene Derivatives
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Boranes
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Coumarins
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Indicators and Reagents
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Phenols
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Water
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boron trifluoride