A novel aromatic iodination method, with sodium periodate used as the only iodinating reagent

Piotr Luliński; Maciej Sosnowski; Lech Skulski

doi:10.3390/10030516

A novel aromatic iodination method, with sodium periodate used as the only iodinating reagent

Molecules. 2005 May 13;10(3):516-20. doi: 10.3390/10030516.

Authors

Piotr Luliński¹, Maciej Sosnowski, Lech Skulski

Affiliation

¹ Chair and Laboratory of Organic Chemistry, Faculty of Pharmacy, Medical University, Banacha 1, PL 02-097 Warsaw, Poland.

Abstract

Benzene, halobenzenes and some deactivated arenes readily reacted in anhydrous NaIO4/AcOH/Ac2O/concd. H2SO4 mixtures to afford, after quenching with excess aqueous Na2SO3 solution (a reducing agent), purified iodinated products in 27-88% yields. This novel method of aromatic iodination is simple, fairly effective and environmentally safe.

MeSH terms

Benzene Derivatives
Indicators and Reagents
Inorganic Chemicals
Iodine*
Organic Chemicals*
Periodic Acid / chemistry*

Substances

Benzene Derivatives
Indicators and Reagents
Inorganic Chemicals
Organic Chemicals
Periodic Acid
Iodine
metaperiodate